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Vol. 29 No. 6 (2017): Vol 29 Issue 6

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[TPA][Pro] Ionic Liquid as Efficient Reaction Medium for N-tert-Boc Protection of Amines

https://doi.org/10.14233/ajchem.2017.20479
T. Vijaya Durga
Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar-522 510, India
A. Rambabu
Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar-522 510, India
M. Srinivasa Reddy
Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar-522 510, India
B. Hari Babu
Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar-522 510, India

Corresponding Author(s) : B. Hari Babu

dr.b.haribabu@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 6 (2017): Vol 29 Issue 6

Abstract

A facile and efficient N-tert-Boc protection of amines is described by the reaction of various primary, secondary, benzylic and aryl amines with di-tert-butyl dicarbonate in the ionic liquid [TPA][Pro] at room temperature. All the N-tert-butylcarbamates are afforded in excellent yields. A catalyst-free method was developed and the ionic liquid [TPA][Pro] can be recovered and reused for several times without loss of its activity.

Keywords

Ionic liquid [TPA][Pro] Amines N-tert-butylcarbamates N-tert-butoxycarbonylation
Durga, T. V., Rambabu, A., Reddy, M. S., & Babu, B. H. (2017). [TPA][Pro] Ionic Liquid as Efficient Reaction Medium for N-tert-Boc Protection of Amines. Asian Journal of Chemistry, 29(6), 1313–1316. https://doi.org/10.14233/ajchem.2017.20479
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