Physico-chemical Aspects of Serum Nitrite Expression by Iron and Glutathione

Abstract

In the present study the effect of NaNO₂ and sodium nitrorpusside (Na-Np) on binding parameters of some iron complexes as well as reduction effects of glutathione and cysteine and their pH equilibrium has been reported. Serum nitrite levels of patients with iron related diseases and in vitro effects of addition of iron containing compounds and glutathione and cysteine on these are also presented. Significant variation in these levels appears to suggest some kind of correlation of NO levels to binding of iron complexes and glutathione. Physico-chemical parameters appear to be significant and relevant to serum nitrite level regulation.