Synthesis and CNS Depressant Activity of Some New Mannich Bases of 1-(4-Dimethylamino)phenyl-4-methyl-pent-1-en-3-one
Corresponding Author(s) : A. Rajasekaran
Asian Journal of Chemistry,
Vol. 16 No. 2 (2004): Vol 16 Issue 2
Abstract
4-Dimethylaminobenzaldehyde was condensed with 2-butanone in presence of 10% sodium hydroxide to yield 1-(4-dimethylamino) phenyl-4-methyl-pent-1-en-3-one (I). Six new mannich bases have been synthesized by the interaction of 1 with six different secondary amines in the presence of paraformaldehyde. All the synthesized compounds were characterized by IR and 1H-NMR spectra and evaluated for CNS depressant activity.
Keywords
Synthesis
CNS-Depressant
Mannich Base
1-(4-Dimethylamino)phenyl-4-methyl-pent-1-en-3-one
(1)
Rajasekaran, A.; Murugesan, S. Synthesis and CNS Depressant Activity of Some New Mannich Bases of 1-(4-Dimethylamino)phenyl-4-Methyl-Pent-1-En-3-One. ajc 2016, 16, 791-794.
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX