Synthesis and Biological Activity of 4-[5(4-Substituted phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Abstract

Esterification of trifluoroacetic acid with ethanol gives ethyl trifluoroacetate (1). Diazotization of sulphanilamide followed by reduction with sodium sulphite leads to the 4-(sulfamoylphenyl)hydrazine hydrochloride (2). Condensation of (1) with substituted acetophenone (3a–d) gave (4a–d), which on treatment with (2) results in the formation of 4-[5-(4-substituted phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (5a–d). The structures of the newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for their biological activity.