Studies on Vilsmeier-Haack Reaction: Preparation and Synthetic Applications of Synthones 4-Chloro-2-arylamino thiazole-5-carboxaldehydes

Abstract

2-Aryliminothiazolid-4-ones (3b–h) were formylated using Vilsmeier-Haack (V-H) reagent. The formylated synthones were used to synthesise various fused heterocyclic ring systems containing thiazole moiety and some heterocyclic Schiff bases to get some compounds of interesting biological activities. These synthones were also subjected to functional group inter-conversion followed by self-condensation to build linear furo-2-arylamino thiazolyl derivatives by a simple route.