Synthesis of 3-[3-(4´-Methylbenzenesulfonamido)phenyl]-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines

Abstract

3-Aminoacetophenone was condensed with 4-toluenesulfonyl chloride to give 3-(4-methylbenzenesulfonamido)acetophenone (1) which on treatment with various aromatic aldehydes afforded 3-[3-(4´-methylbenzenesulfonamido)phenyl]-3-(4-substituted phenyl)-2-propoene-1-ones (2a–e). The compounds (2a–e) on cyclization with hydrazine hydrate in glacial acetic acid furnished 3-[3-(4´-methylbenzenesulfonamido)phenyl]-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines (3a–e). The constitution of the products was supported by IR, NMR, mass spectral data and elemental analysis. All the compounds synthesized have been screened for their biological activity.