Synthesis and Characterization of the Copper(II) Complex of a Nucleic Acid Constituent, Adenosine

Abstract

Copper(II)-adenosine complex has been synthesized in aqueous medium (pH 6) and characterized by elemental analysis, infrared, ¹H NMR electronic spectral and magnetic moment data and ESR study. From IR spectral analysis it is concluded that the C₆–NH₂ group and N₇ nitrogen of adenosine is involved in coordination with Cu(II) ion. This is most probable as it leads to formation of stable five-membered chelate ring. The formation of Cu–Cl bond is also evident from elemental analysis and the IR spectral data. The binding mode has also been confirmed from ¹H NMR studies. From electronic spectral analysis, it is proposed that the Cu(II)-adenosine complex assumes predominantly a square-planar geometry. This is also supported by magnetic moment measurements and EPR studies.