Synthesis and Evaluation of Ibuprofen Conjugate with Salicylamide and its Mannich Bases for Analgesic and Antiinflammatory Activities
Corresponding Author(s) : M.S. Vijay Kanth
msvijaykanth@rediffmail.com
Asian Journal of Chemistry,
Vol. 17 No. 2 (2005): Vol 17 Issue 2
Abstract
Ibuprofen conjugate with salicylamide and its Mannich bases were synthesized and characterized using melting point, TLC, elemental analysis, IR spectroscopy, NMR and mass spectroscopy. Further, the compounds were screened for pharmacological activity which indicated that some Mannich bases of mutual prodrug of ibuprofen and salicylamide were better than their individual parent compound and its mutual prodrug for its analgesic and antiinflammatory activities. They also had lesser ulcerogenic index, an indication of lesser toxicity.
Keywords
Ibuprofen
Salicylamie
Analgesic
Mannich base
Antiinflammatory activity
K. Nair, D., Mishra, A., & Vijay Kanth, M. (2016). Synthesis and Evaluation of Ibuprofen Conjugate with Salicylamide and its Mannich Bases for Analgesic and Antiinflammatory Activities. Asian Journal of Chemistry, 17(2), 943–948. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/14331
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