Synthesis and Antimicrobial Activity of New 3-Amino sulphonyl[3´-chloro-4´-(substituted phenyl)-2´-oxo azetidine]indole

Abstract

A series of new 3-amino sulphonyl[3´-chloro-4´(substituted phenyl)-2´-oxo azetidine]indole derivatives (5a-j) have been prepared from the respective 3-(substituted benzylidene hydrazine) sulphonyl indoles (4a-j) by treating with chloracetyl chloride in presence of ethanol. The required substituted benzylidene hydrazino sulphonyl indoles (4a-j) were obtained from hydrazino sulphonyl indole (3) by condensing with appropriate aromatic aldehydes. Chloro-sulphonyl indole (2) when treated with hydrazine yielded the respective hydrazides. 3-Aminosulphonyl [3´-chloro-4´-(4-nitrophenyl)-2´-oxo azetidine]indole showed moderate to good antimicrobial activity.