Synthesis of Some New Thiazolo Pyrimidines Using Cyclocondensation Reaction

Abstract

Reaction of pyrimidine derivative 1 with chloroacetyl chloride under reflux condition in dioxane afforded fused pyrimidines 2(a-d). In a similar way fused thiazolo pyrimidine compounds 3(a-f) were synthesized by reaction of 1, chloroacetic acid, acetic anhydride, acetic acid and corresponding aldehyde. Yields of the products following recrystallizaton from ethanol were of the order of 66-93%. IR, ¹H NMR and mass spectroscopies and in some cases elemental analysis were used for identification of these compounds.