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Vol. 29 No. 5 (2017): Vol 29 Issue 5

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A Novel Process for Synthesis of Rosuvastatin

https://doi.org/10.14233/ajchem.2017.20396
D. Nagender Rao
Inogent Laboratories Private Limited, Department of Research & Development, 28A, IDA, Nacharam, Hyderabad-500 076, India; Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India
Reguri Buchi Reddy
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India; IPCA Laboratories Ltd, Chemical Research and Development, Plot-123AB, Charkop, Kandivali Industrial Area, Kandivali (West), Mumabi-400 067, India
K. Mukkanti
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India
Venu Konda
Inogent Laboratories Private Limited, Department of Research & Development, 28A, IDA, Nacharam, Hyderabad-500 076, India

Corresponding Author(s) : D. Nagender Rao

nagenderchem@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 5 (2017): Vol 29 Issue 5

Abstract

A novel process for the preparation of antihypercholesterolemic drug rosuvastatin calcium using novel intermediates has been described. Novel intermediates have been characterized by using IR, NMR and Mass spectroscopy.

Keywords

Rosuvastatin calcium Antihypercholesterolemic drug N-methylmorpholine Triphenylphosphine
Rao, D. N., Reddy, R. B., Mukkanti, K., & Konda, V. (2017). A Novel Process for Synthesis of Rosuvastatin. Asian Journal of Chemistry, 29(5), 1018–1022. https://doi.org/10.14233/ajchem.2017.20396
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References
  1. A.G. Olsson, F. Mc Taggart and A. Raza, Cardiovasc. Drug., 20, 303 (2002); https://doi.org/10.1111/j.1527-3466.2002.tb00099.x.
  2. M.E. Brousseau, IDrugs, 6, 458 (2003).
  3. P. Rubba, G. Marotta and M. Gentile, Vasc. Health Risk Manag., 5, 343 (2009); https://doi.org/10.2147/VHRM.S3662.
  4. G.G. Schwartz, M.A. Bolognese, B.P. Trembly, R. Caplan, H. Hutchinson, A. Raza and M. Cressman, Am. Heart J., 148, 105 (2004); https://doi.org/10.1016/j.ahj.2004.01.020.
  5. Y. Saito, N. Yamada, K. Shirai, K. Sasaki, Y. Ebihara, T. Yanase and J.C. Fox, Artheosclerosis, 194, 505 (2007); https://doi.org/10.1016/j.atherosclerosis.2006.11.028.
  6. K. Hirai, T. Ishiba, H. Koike and M. Watanable, Pyrimidine Derivatives, U.S. Patent 5,260,440 (1993).
  7. P.T. Nigel, L.J. Diorazio, H. Koike and M. Kabaki, Process for the Production of tert-Butyl (E)-(6-[2-[4-(4-Flurophenyl)-6-isopropyl-2-[methyl(methylsufonyl)amino]pyrimidin-5-yl]vinyl]4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetate, U.S. Patent 6844437 B1 (2005).
  8. S.D. Dwivedi, D.J. Patel and M.L. Rupapara, Hmg-coa Reductase Inhibitors and Process for the Preparation Thereof, W.O Patent 2011104725A2 (2011).
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