Synthesis, Characterization and Antimicrobial Activities of Platinum(II) and Palladium(II) Complexes with Various Donor Ligands: Part (I)

Abstract

Several platinum(II) and palladium(II) complexes of the general formula cis-[MLL´X₂], M = Pt or Pd, L = L´ = DMSO, X = Cl, ½C₂O₄, ½(OCO)₂-CCH₂CH₂CH₂, ½{(OCO)CH=CH(OCO)}, (OCO)C₆H₁₁; M = Pt or Pd, L = DMSO, L´ = harmaline or harmine, X = Cl, ½C₂O₄, ½(OCO)₂-CCH₂CH₂CH₂; M = Pt, L = 3,5-dimethylpyrozole, L´ = harmine; and trans-[Pd(3,5-dimethylpyrazole)₂Cl₂] have been prepared and characterized physico-chemically and spectroscopically. These complexes together with the antibiotic ciprofloxacin and antifungal miconazole nitrate were tested for their antimicrobial activity against the two gram-negative bacterial species, Escherichia coli and Pseudomonas aeruginosa, and the gram-positive bacterial species, Staphylococcus aureus and the fungal species, Candida albicans. The results obtained were compared with those of the platinum complexes, cisplatin, carboplatin and oxaliplatin; the known anticancer drugs.