Analytical Determination of Antihistamine Drugs in Pure and Its Pharmaceutical Formulations

Abstract

A quick and convenient method has been developed for the micro estimation of antihistamine drugs. 1–5 mg of sample is allowed to react with 10 mL of 0.02 M, N-bromosaccharin solution. Unconsumed reagent can be accurately titrated with 5 mL of 15% KI and 0.02 N sodium thiosulphate solution using starch as indicator. SD and CV was calculated for reproducible and accurate result. The accuracy of the method is within ± 1%.