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Vol. 17 No. 3 (2005): Vol 17 Issue 3

Nature of the Main Contaminant in the Drug Primaquine Diphosphate: GC-MS Analysis

Ilia Brondz
Department of Molecular Biosciences, University of Oslo, P.O. Box 1041, Blindern, 0316 Oslo, Norway
Uwe Klein
Department of Molecular Biosciences, University of Oslo, P.O. Box 1041, Blindern, 0316 Oslo, Norway
Dimitris Mantzilas
Department of Molecular Biosciences, University of Oslo, P.O. Box 1041, Blindern, 0316 Oslo, Norway
Dag Ekeberz
Department of Chemistry and Biotechnology, Section Chemistry, Agricultural University of Norway, P.O. Box 5040, 1432, Ås, Norway
Erlend Hvattum
Department of Chemistry and Biotechnology, Section Chemistry, Agricultural University of Norway, P.O. Box 5040, 1432, Ås, Norway
Henrk Schultz
Weifa AS, Hausmanns gt. 6, P.O. Box 9113, Gronland, 0133 Oslo, Norway
Felix Mikhailitsyn
Martsinovsky Institute of Medical Parasitology and Tropical Medicine, 20 Malaja Pyrogovskaja St., Moscow, Russia

Corresponding Author(s) : Ilia Brondz

ilia.brondz@biokjemi.uio.no

Asian Journal of Chemistry, Vol. 17 No. 3 (2005): Vol 17 Issue 3

Abstract

In the present work, GC-MS was used to provide evidence on fragmentation differences between primaquine and quinocide. Primaquine and quinocide are readily separated by GC. Both substances give visible M+ molecular ion 259 m/z. The base peak in the mass spectrum of primaquine was found to be at m/z 201, in the mass spectrum of the positional-isomer quinocide the base peak was found to be at m/z 187. Two detailed MS fragmentation schemes for primaquine and quinocide are provided which can help to identify primaquine-like derivatives. Using GC-MS, it is possible to recognize with high confidence the positional-isomer contaminant in gas chromatograms of the antimalaria drug primaquine without a standard substance as reference.

Keywords

Primaquine Quinocide MS fragmentation GC-MS
(1)
Brondz, I.; Klein, U.; Mantzilas, D.; Ekeberz, D.; Hvattum, E.; Schultz, H.; Mikhailitsyn, F. Nature of the Main Contaminant in the Drug Primaquine Diphosphate: GC-MS Analysis. ajc 2016, 17, 1678-1688.
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