Synthesis and Antibacterial Activity of N'-(Substituted Phenylidene Hydrazido)-2-Methylthiazole-4-yl Acetamides

Abstract

Arylidene derivatives of ethyl-2-methylthiazole-4-acetic acid were synthesized by condensing ethyl ester of 2-methyl thiazole-4-acetic acid and hydrazine hydrate followed by the reaction with respective aldehydes. These are characterized on the basis IR, NMR and mass spectral data. The synthesized compounds were evaluated for antibacterial activity against organisms Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and Staphylococcus aureus.