A Suitable Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones by Microwave Irradiation

M.A. Pa Sha; V.P. Jaya Shankara

Issue

Vol. 17 No. 3 (2005): Vol 17 Issue 3

Issue Published : March 19, 2005

A Suitable Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones by Microwave Irradiation

M.A. Pa Sha

Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore-560 001, India

V.P. Jaya Shankara

Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore-560 001, India

Corresponding Author(s) : M.A. Pa Sha

Asian Journal of Chemistry, Vol. 17 No. 3 (2005): Vol 17 Issue 3
Article Published : May 16, 2016

Abstract

Zinc acetate dihydrate (Zn(OAc)₂·2H₂O) efficiently catalyzes the three-component coupling of b-keto ester, substituted aryl adehyde and urea or thiourea to afford the corresponding 3,4-dihydro-pyrimidin-2(1H)-ones/thiones respectively, the new protocol for the Biginelli reaction under microwave irradiation works in the absence of solvent. The yields are high and the reaction goes to completion within 40–60 sec.

Keywords

Microwave irradiation b-Keto ester Aryl benzaldehyde Urea Thiourea 3,4-Dihydropyrimidin-2(1H)ones

Pa Sha, M., & Jaya Shankara, V. (2016). A Suitable Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones by Microwave Irradiation. Asian Journal of Chemistry, 17(3), 1858–1862. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/14052

Issue

Vol. 17 No. 3 (2005): Vol 17 Issue 3

A Suitable Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones by Microwave Irradiation

Corresponding Author(s) : M.A. Pa Sha

Abstract

Keywords

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