Microwave Synthesis of Novel Imidazetines as Bilactam Antimicrobial Agents

Abstract

The condensation of various substituted phenyl urea and monocarboxylic acids were carried out by conventional method using hydrochloric acid (4 N). The amides and acids in ethanol were also condensed under microwave irradiation since the time utilized by the conventional method was so long, up to 10 h. The results indicate that microwave irradiation enhances the rate of reaction and the yield was also improved. Minimum inhibitory concentrations were determined by serial dilution method and the zones of inhibition against various pathogens were also determined using cup-plate method. The compounds synthesized exhibited varying degrees of antimicrobial activity and the lyses produced were comparable with the standard drugs.