Hepatoprotective Activity of Coccinia grandis (Linn.) Fruit Extracts on Carbontetrachloride Induced Liver Damage in Rats

Abstract

In hepatotoxic rats, liver damage was studied by assessing functional parameters like pentobarbitone sleeping time and biochemical parameter like serum alanine transaminase, aspirate transiminase, serum alkaline phosphate, serum acid phosphate, serum bilirubin, serum cholesterol and serum triglycerides. Methyl alcohol extract and aqueous extract of Coccinia grandis inhibited CCl₄ induced liver toxicity in albino rats as assessed by the functional values and biochemical values, which show the significant hepatoprotective activity.