Synthesis and Biological Evaluation of 2-Arylidene-4-(4-methoxy-phenyl)but-3-en-4-olides

Abstract

Fifteen new 2-arylidene-4-(4-methody-phynyl)but-3-en-4-olides have been synthesized by condensing 3-(4-methoxy benzoyl)propionic acid with appropriate aromatic aldehydes in presence of triethylamine. The compounds have been evaluated for their antimicrobial and antiinflammatory activities. Their structures were established on the basis of elemental analysis, IR and ¹H NMR spectral data.