Synthesis and Characterization of Schiff Bases of 2'-Amino-4-(6-chloro-3-coumarinyl)thiazole as Potential NSAIDs

Abstract

Some of the Schiff bases of aminothiazolylchlorocoumarin are synthesized by the reaction between 2'-amino-4'-(6-chloro-3-coumarinyl)thiazole and substituted aromatic aldehydes. The former is obtained by cyclization of 3-bromoacetyl-6-chlorocoumarin and thiourea. The resulting compounds are characterized by spectral data and evaluated for their analgesic and anti-inflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Few of the compounds have shown interesting biological activity based on the presence of certain functional groups.