Pentyl Thiourea Derivatives as Potential Growth Inhibitor Towards Oscillatoria sp.

Abstract

Nowadays, our aquatic environment is currently being polluted by harmful algal blooms, which affect water quality and eventually kill aquatic organisms. Many efforts have been carried out to overcome the problem but the methods are either money-consuming or non-environmental friendly. Therefore, this study was aimed to inhibit the growth of Oscillatoria sp. isolated from Kenyir lake in the state of Terengganu, Malaysia using the synthesized pentyl-thiourea derivatives (1-4). The series of compounds were successfully synthesized and spectroscopically characterized via infrared analysis and ¹H and ¹³C NMR spectroscopy. The IR spectra of all the compounds showed five expected important stretching bands of interest which were n(N-H), n(C-H), n(C=O), n(C-N) and n(C=S). In turn, they were introduced towards Oscillatoria sp. culture at different concentration of 2-10 μg/mL. All these compounds showed inhibition potential towards the Oscillatoria sp. growth in the range of 6 and 30 %. These types of molecules within thiourea family are indeed are potentially exhibit the growth of Oscillatoria sp.