Use of Redox Reactions for Estimation of Carvedilol

Abstract

Simple and sensitive indirect spectrophotometric methods (M₁ and M₁) for the assay of Carvedilol in dosage forms based on their reactivity with N-bromo succinimide have been described. These methods involve the oxidation of drug with excess of N-bromo succinimide and estimating the unreacted N-bromo succinimide either with celestine blue (M₁) or p-N-methyl amino phenol sulfate-sulfanilamide (M₂). The results obtained are reproducible and are statistically validated.