Visible Spectrophotometric Methods for Estimation of Ambroxol Hydrochloride from Tablet Formulation

Abstract

Two simple visible spectrophotometric methods have been developed for the estimation of ambroxol hydrochloride from tablet formulation. The developed methods were based on formation of chloroform extractable yellow coloured chromogen of drug with bromocresol green and chlorophenol red, which shows absorbance maxima at 422.0 and 371.0 nm and linearity in the concentration range of 10–120 and 200–1200 μg/mL of drug respectively. Results of analysis for both the developed methods were validated statistically and by recovery studies.