Stability Test of Acyclovir at Severe Conditions

A. Hamdi; R. Fegas; B. Berka; B.J. Clarck

Issue

Vol. 17 No. 4 (2005): Vol 17 Issue 4

Issue Published : 5 August 2005

Stability Test of Acyclovir at Severe Conditions

A. Hamdi

Facult de Chimie, USTHB BP 32 El Alia Bab Ezzouar 16111 Alger, Algeria

R. Fegas

ENS Departement de Chimie, Kouba, Alger, Algeria

B. Berka

Facult de Chimie, USTHB BP 32 El Alia Bab Ezzouar 16111 Alger, Algeria

B.J. Clarck

Pharmaceutical Chemistry Department, School of Pharmacie, Bradford, UK

Corresponding Author(s) : A. Hamdi

ahamdi_dz@yahoo.fr

Asian Journal of Chemistry, Vol. 17 No. 4 (2005): Vol 17 Issue 4
Article Published : 7 June 2016

Abstract

In this paper, the influence of stability of acyclovir in severe conditions was tested (acid and alkaline environment) and the acyclovir impurities were evaluated using ion-pairing HPLC method and mobile phase H₂O : ACN 5 : 95% (v/v) counter-ion C₈H₁₇SO₄ Na 0.002 M, pH 2.5, KH₂PO₄ 0.02 M, flow rate 1 mL/min, UV detection 253 nm. The method was precise and linear (R > 0.99985, n = 11) in the range of 1-100 μg/mL and reproducible (RSD = 2.65%).

Keywords

HPLC Ion-pair Acyclovir Guanine Stability

(1)

Hamdi, A.; Fegas, R.; Berka, B.; Clarck, B. Stability Test of Acyclovir at Severe Conditions. ajc 2016, 17, 2699-2704.

Issue

Vol. 17 No. 4 (2005): Vol 17 Issue 4

Stability Test of Acyclovir at Severe Conditions

Corresponding Author(s) : A. Hamdi

Abstract

Keywords

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