Utilizing 85% H2SO4 in One Pot Synthesis of 5-Mono- and 3,5-Disubstituted g-Butyrolactones

Abstract

One pot synthesis of several 5-monosubstituted dihydro-furan-2-ones such as 5-ethyl-dihydro-furan-2-one (1a), 5-propyl-dihydro-furan-2-one (1b), 5-pentyl-dihydro-furan-2-one (1c) and 5-hexyl-dihydro-furan-2-one (1d) (with a strong to mild coconut fragrance) and several disubstituted dihydro-furan-2-ones such as 3-benzyl-5-propyl-dihydro-furan-2-one (1e), 3-benzyl-5-n-hexyl-furan-2-one (1f), 3-butyl-5-n-hexyl-furan-2-one (1g) and 3-buthyl-5-propyl-furan-2-one (1h) in the presence of 85% H₂SO₄ in 40-62% yields is described.