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Vol. 29 No. 4 (2017): Vol 29 Issue 4

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A Novel Synthesis and Characterization of 1,2,3,4-Tetrahydropyrimidin-2(1H)-thiones

https://doi.org/10.14233/ajchem.2017.20346
N. Krishna Rao
Department of Chemistry, Krishna University, Machilipatnam-521 002, India
M.S. Surendra Babu
Department of Chemistry, GITAM University, Hyderabad-502 329, India
M.V. Basaveswara Rao
Department of Chemistry, Krishna University, Machilipatnam-521 002, India
Tentu Nageswara Rao
Department of Chemistry, Krishna University, Machilipatnam-521 002, India
Karri Apprao
Department of Chemistry, Krishna University, Machilipatnam-521 002, India
G. Kumar
Department of Chemistry, Krishna University, Machilipatnam-521 002, India

Corresponding Author(s) : N. Krishna Rao

nkrishnarao@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 4 (2017): Vol 29 Issue 4

Abstract

We reported the use of Brønsted acid methane sulfonic acid as a promoter for three component Biginelli cyclocondensation reaction of aryl aldehydes, acetylacetone and thiourea at 120 °C to afford the corresponding to 1,2,3,4-tetrahydropyrimidin-2(1H)-thiones in good to excellent yields in short span of time. Reaction is efficient, facile and rapid. The structural elucidation of products was done by NMR, IR and elemental analysis.

Keywords

Biginelli cyclocondensation Acetylacetone Arylaldehydes Thiourea Methanesufonic acid 1,2,3,4-Tetrahydropyrimidithione
Rao, N. K., Babu, M. S., Rao, M. B., Rao, T. N., Apprao, K., & Kumar, G. (2017). A Novel Synthesis and Characterization of 1,2,3,4-Tetrahydropyrimidin-2(1H)-thiones. Asian Journal of Chemistry, 29(4), 882–884. https://doi.org/10.14233/ajchem.2017.20346
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