Antidiabetic Activity of Methoxy Bergenin Isolated from Ethanol Extract of Raru Stem Bark (Vatica pauciflora Blume) in Alloxan Induced Diabetic Wistar Rats

Abstract

This paper describes the potential of methoxy bergenin isolated from ethanol extract of the raru stem bark (Vatica pauciflora Blume) to be antidiabetics. In the experiment, each of the alloxan induced wistar rats group is given a dose of 65 mg/200 g BB/2 mL, 130 mg/200 g BB/2 mL and 195 mg/200 g BB/2 mL of methoxy bergenin. On the day of 14 and 21 of treatment, the blood sugar levels of wistar rats are measured by a glucometer. The ANOVA result showed there are the different effects of methoxy bergenin on the blood sugar levels of wistar rats significantly. The dose of 195 mg/200 g BB/2 mL on day 21, give the best effect of a decrease in the blood sugar levels. The t_test results showed the wistar rats’s body weight are also decreased significantly after 21 days of treatment. Based on these the methoxy bergenin has a potential as an antidibetics which resembles acarbose.