Synthesis of 1-Phenyl-3-(pyridine-4-yl)prop-2-ynyl Acetate
Corresponding Author(s) : RAMAZAN ERENLER
rerenler@gop.edu.tr
Asian Journal of Chemistry,
Vol. 19 No. 3 (2007): Vol 19 Issue 3
Abstract
The propargyl alcohol (3) was synthesized by the treatment of benzaldehyde (1) with trimethylsilylacetylene and n-butyl lithium in THF at -78ºC. After removing of trimethylsilyl with KOH in MeOH, 1-phenylprop-2-yn-1-ol (4) was obtained. The coupling of this compound 4 with 4-bromopyridine yielded the 1-phenyl-3-(pyridin-4-yl)prop-2-yn-1-ol (5) which was converted to acetate 6 via acetic anhydride.
Keywords
Coupling reaction
1-Phenyl-3-(pyridine-4-yl)prop-2-ynyl acetate
ERENLER, R. (2010). Synthesis of 1-Phenyl-3-(pyridine-4-yl)prop-2-ynyl Acetate. Asian Journal of Chemistry, 19(3), 2207–2210. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/13798
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