Issue

Vol. 19 No. 3 (2007): Vol 19 Issue 3

Synthesis, Crystal Structure and Antibacterial Properties of N-(2-Hydroxy-1-naphthalidene)-4-aminoantipyrine

FENG GUO
Key Labaoratory of Marine Chemistry, Theory and Technology, Ministry of Education, Ocean University of China, Qingdao-266 003, P.R. China
CAI-FENG BI
Key Labaoratory of Marine Chemistry, Theory and Technology, Ministry of Education, Ocean University of China, Qingdao-266 003, P.R. China
YU-HUA FAN
Key Labaoratory of Marine Chemistry, Theory and Technology, Ministry of Education, Ocean University of China, Qingdao-266 003, P.R. China
YAN XIAO
Key Labaoratory of Marine Chemistry, Theory and Technology, Ministry of Education, Ocean University of China, Qingdao-266 003, P.R. China
XUE-TAO HE
Key Labaoratory of Marine Chemistry, Theory and Technology, Ministry of Education, Ocean University of China, Qingdao-266 003, P.R. China
JIA-KUN XU
Key Labaoratory of Marine Chemistry, Theory and Technology, Ministry of Education, Ocean University of China, Qingdao-266 003, P.R. China

Corresponding Author(s) : CAI-FENG BI

bcfeng@ouc.edu.cn, guofeng1510@yeah.net

Asian Journal of Chemistry, Vol. 19 No. 3 (2007): Vol 19 Issue 3

Abstract

The structral features of Schiff base (N-(2-hydroxy-1- naphthalidene)-4-aminoantipyrine) formed by the interaction of 4-aminoantipyrine and 2-hydroxy-1-naphthaldehyde with the formula C22H19N3O2 has been determined by X-ray diffraction method and elemental analysis. The crystal belongs to orthorhomic system with space group P2(1)2(1) 2(1), a = 8.8170(18) Å, b = 14.605(3) Å, c = 14.734(3) Å, V = 1897.3(7) Å-3, Z = 4, R1 = 0.0414, wR2 = 0.1063, F(000) = 752, respectively for 2306 observed reflections. In addition, the compound has been tested for its antibacterial active. The compound showed antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and had no antibacterial activity against Bacillus subtilis.

Keywords

Schiff base Crystal structure Antibacterial activity
GUO, F., BI, C.-F., FAN, Y.-H., XIAO, Y., HE, X.-T., & XU, J.-K. (2010). Synthesis, Crystal Structure and Antibacterial Properties of N-(2-Hydroxy-1-naphthalidene)-4-aminoantipyrine. Asian Journal of Chemistry, 19(3), 1846–1852. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/13751
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