(±) Menthol (1) was oxidized to menthone (2) which was reacted with hydroxylamine hydrochloride to yield menthone oxime (3). The menthone oxime (3) was converted to (2s, 5r)-(±)-2-isopropyl-5-methyl-1-azacycloheptane-7-one (4) via Schmidt reaction, which was reacted with various substituted aromatic benzoyl chlorides in alkaline medium to yield various phenyl substituted 1-benzoyl-7-isopropyl-4-methylazepan-2-one derivatives (5a-g). The structure of newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for analgesic activity.
Keywords
SynthesisBenzoyl derivativesAnalgesic activity
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GUPTA, S., N. PANDEYA, S., KUMAR, P., TRIPATHI, L., PRASHANT, P., & VERMA, K. (2010). Synthesis and Analgesic Activity of Some New Benzoyl Derivatives. Asian Journal of Chemistry, 19(4), 2891–2895. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/13396