Evaluation of Antidiarrhoeal Activity of Thunbergia fragrans Roxb.
Corresponding Author(s) : D. SHESHADRI SHEKHAR
Asian Journal of Chemistry,
Vol. 19 No. 4 (2007): Vol 19 Issue 4
Acetonic and ethanolic extracts of Thunbergia fragrans (Acanthaceae) leaves on gastrointestinal motility was investigated by using Swiss albino mice. Acetonic and ethanolic extracts at dose of 500 mg/kg body weight were orally administered to mice. The antidiarrhoeal activity was evaluated using charcoal meal model and castor oil induced diarrhoea model in albino mice. Both extracts demonstrated a significant antidiarrhoeal activity (p < 0.001). These observations prove the antidiarrhoeal activity of T. fragrans. The acute toxicity studies of these two extracts upto a dose level of 2000 mg/kg body weight of the mice showed no mortality.
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