Synthesis and Antimicrobial Activity of 2-Alkyl/aryl-5-(pyrid-4-yl)-1,3,4-oxadiazole

Abstract

Some new 2-substituted-5-(pyrid-4-yl)-1,3,4-oxadiazoles (IIIa-f) have been synthesized by oxidative cyclization of N-substituted isoniazids (IIa-f) with molecular iodine in presence of alkali in ethanolic medium. The latter have been synthesized by condensing isoniazid with different acid chlorides (Ia-f). All these compounds were screened for their antimicrobial activity against gram positive and gram negative microorganisms.