Synthesis and Antimicrobial Activity of Disubstituted Arylphosphoric Diamide
Corresponding Author(s) : SHASHI PRABHA
Asian Journal of Chemistry,
Vol. 19 No. 4 (2007): Vol 19 Issue 4
Abstract
Synthetic o-nitro-p-chloro-phenyl phosphoric diamide hydrolyses via neutral and the conjugate acid species, with two rate maxima (2 and 5 M HCl) at 40 (± 0.5)°C in 12 % DMSO-H2O mixture. Specific acid catalysis bimolecular mode and P-N bond fission, all leading to two mechanistic routes of hydrolysis have been established. The special feature is the intervention of the corresponding monoester during acid hydrolysis. Antifungal activity of C-N-P ester has been observed for C. albicans and C. neoformans.
Keywords
Phosphoric diamide
Bimolecular and Antifungal activity
PRABHA, S., & SAXENA, A. (2010). Synthesis and Antimicrobial Activity of Disubstituted Arylphosphoric Diamide. Asian Journal of Chemistry, 19(4), 2672–2678. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/13362
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