RP-HPLC Method for the Estimation of Racecadotril in Bulk and in Tablets
Corresponding Author(s) : J.V.L.N. SESHAGIRI RAO
Asian Journal of Chemistry,
Vol. 19 No. 4 (2007): Vol 19 Issue 4
Abstract
A rapid and precise RP-HPLC method has been developed for the estimation of racecadotril in pure form as well as in pharmaceutical dosage forms. The quantification was carried out using an ODS column (250 × 4.6 mm ID), 5 μ particle size with a mobile phase comprising of water and acetonitrile in the ratio 30 : 70 (v/v) in isocratic mode at a flow rate of 1.0 mL/min. The eluent was monitored at 211 nm. The retention time was 5.85 min. Aceclofenac was used as an internal standard. The method was duly validated by evaluation of the required parameters. The calibration curve was linear in the concentration range of 0.5-100 μg/mL and the percentage recovery ranged from 99.8-100.6.
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