Microwave Assisted Synthesis and Bioactivity of s-Triazolo[3,4-b][1,3,4]thiadiazoles, s-Triazolo[3,4- b][1,3,4]thiadiazines and s-Triazolo[3',4':2,3]thiadiazino [5,6-b]quinoxaline: Part-III
Corresponding Author(s) : MAHENDRA SHIRADKAR
Asian Journal of Chemistry,
Vol. 19 No. 4 (2007): Vol 19 Issue 4
Abstract
The condensation of N-[3-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-4,5-dimethyl thiophene-2-yl]benzamide (I) with chloroacetic acid, α-haloketone and benzoin furnished condensed products [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives viz., II, III, IV, respectively, while condensation with 2,3-dichloro quinoxaline, carbon disulphide, aromatic carboxylic acid and aromatic carboxaldehydes furnished the cyclic products [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives viz., V, VI, VII, VIII, respectively. The compounds have been characterized on the basis of elemental analysis and spectral data. The antibacterial, antifungal and antitubercular activities of the compounds have also been evaluated.
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