Synthesis and Characterization of Some 1,4-Dihydropyridine Derivatives Containing Dichlorothiazolyl Substituents
K.M. TAGHI-GANJI
Faculty of Chemistry, Islamic Azad University, North Tehran - Branch, Tehran, Iran
SH. GHODSI
Faculty of Chemistry, Islamic Azad University, North Tehran - Branch, Tehran, Iran
E. ALIPOUR
Faculty of Chemistry, Islamic Azad University, North Tehran - Branch, Tehran, Iran
M. AMINI
Faculty of Chemistry, Islamic Azad University, North Tehran - Branch, Tehran, Iran
M. HOSSEINI
Faculty of Chemistry, Islamic Azad University, North Tehran - Branch, Tehran, Iran
Tel: (98)(212)2803801; Fax: (98)(212)2222512; E-mail: ej_alipour@yahoo.com
A. SHAFIEE
Faculty of Chemistry, Islamic Azad University, North Tehran - Branch, Tehran, Iran
Corresponding Author(s) : E. ALIPOUR
ej_alipour@yahoo.com
Asian Journal of Chemistry,
Vol. 19 No. 4 (2007): Vol 19 Issue 4
4-Substituted heterocycles or aryl dihydropyridines (DHP) with various C3, C5 diesters have calcium channel antagonist activity. In this paper a group of dialkyl, dicycloalkyl and diaryl ester analogues of nifedipine, in which the ortho nitro phenyl group at position 4 is replaced by 2,4-dichloro-5-thiazolyl substituent is presented. The Hantzsch condensation of alkyl acetoacetate (3) and ammonium acetate with 2,4-dichloro-1,3-thiazole-5-carboxaldehyde (2) offered symmetrical dialkyl 1,4-dihydro-2,6-dimethyl-4-(2,4-dichloro-1,3-thiazolyl)-3,5-pyridinedicarboxylates. Whereas condensation of 2 with 3 and 5 gave the asymmetrical dialkyl esters.
TAGHI-GANJI, K., GHODSI, S., ALIPOUR, E., AMINI, M., HOSSEINI, M., & SHAFIEE, A. (2010). Synthesis and Characterization of Some 1,4-Dihydropyridine Derivatives Containing Dichlorothiazolyl Substituents. Asian Journal of Chemistry, 19(4), 2521–2526. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/13337
