Variations in the Physico-chemical Parameters of Some 5a and 5b Substituted Barbiturate Derivatives
Corresponding Author(s) : S.N. LIMAYE
snl222@yahoo.co.in
Asian Journal of Chemistry,
Vol. 19 No. 4 (2007): Vol 19 Issue 4
Abstract
The barbiturates are therapeutically used as sedative, hyponotic, anaesthetic and anticonvulsant agents. The trienolmoiety and 5-substituents regulate the biological activity regarding the lypophilicity/hydrophobicity values of barbiturates against their physico-chemical properties.
Keywords
Modelling
Hydrophobicity
Therapeutic
Barbiturates
(1)
RAY, R.; HARI KRISHNA, S.; SHARMA, J.; LIMAYE, S. Variations in the Physico-Chemical Parameters of Some 5a and 5b Substituted Barbiturate Derivatives. ajc 2010, 19, 2497-2501.
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