Synthesis of N-Containing Heterocycles via Mechanochemical Grinding and Conventional Techniques

Amin F.M. Fahmy; Amira A. El-Sayed; Magdy M. Hemdan; Aya I. Hassaballah; Ahmed F. Mabied

doi:10.14233/ajchem.2017.20798

Issue

Vol. 29 No. 12 (2017): Vol 29 Issue 12

Issue Published : October 30, 2017

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of N-Containing Heterocycles via Mechanochemical Grinding and Conventional Techniques

https://doi.org/10.14233/ajchem.2017.20798

Amin F.M. Fahmy

Department of Chemistry, Faculty of Science, Ain Shams University, 11566, Abbasia, Cairo Egypt

Amira A. El-Sayed

Department of Chemistry, Faculty of Science, Ain Shams University, 11566, Abbasia, Cairo Egypt

Magdy M. Hemdan

Department of Chemistry, Faculty of Science, Ain Shams University, 11566, Abbasia, Cairo Egypt

Aya I. Hassaballah

Department of Chemistry, Faculty of Science, Ain Shams University, 11566, Abbasia, Cairo Egypt

Ahmed F. Mabied

X-ray Crystallography Lab., Solid State Physics Department, National Research Center, Dokki, Cairo, Egypt; Department of Basic Sciences, October High Institute for Engineering and Technology, 3rd District, 2nd Zone, 6th of October City, Egypt

Corresponding Author(s) : Amira A. El-Sayed

amira_aa47@hotmail.com

Asian Journal of Chemistry, Vol. 29 No. 12 (2017): Vol 29 Issue 12
Article Published : October 30, 2017

Abstract

Mechano heterocyclic chemistry is a recent quickly growing technique draws the attention of hetrocyclic chemists towards the use of grindstone technique in a solvent free green efficient clean synthesis of many heterocyclic systems. a,b-Epoxy ketones were used as a unique scaffold for synthesis of stable hydroxyazoles. The key advantage of grinding technique over the conventional thermal technique includes its simple, solvent free conditions, as well as facile work up with high yield economy. It is also successful in achieving three of the green chemistry objectives of a solvent free, high atom economy, save energy thus combining the features of both economic and environmental advantages.

Keywords

Green chemistry Pyrazoles Oxazoles Imidazolidines Oxazolidines

Fahmy, A. F., El-Sayed, A. A., Hemdan, M. M., Hassaballah, A. I., & Mabied, A. F. (2017). Synthesis of N-Containing Heterocycles via Mechanochemical Grinding and Conventional Techniques. Asian Journal of Chemistry, 29(12), 2679–2686. https://doi.org/10.14233/ajchem.2017.20798

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References

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D.J. Vishal, D.K. Mahendra and S. Sarita, J. Chem. Pharm. Res., 4, 3234 (2012).

E.M. Sharshira and N.M.M. Hamada, Molecules, 17, 4962 (2012); https://doi.org/10.3390/molecules17054962.

A. Verma, S. Joshi and D. Singh, J. Chem., 2013, 1 (2013); https://doi.org/10.1155/2013/329412.

J. Do and T. Friseic, ACS. Cent. Sci., 3, 13 (2017); https://doi.org/10.1021/acscentsci.6b00277.

R.M. Claramunt, C. López, D. Sanz and J. Elguero,Adv. Heterocycl. Chem., 112, 117 (2014); https://doi.org/10.1016/B978-0-12-800171-4.00003-2.

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S. Kumar, Green Chem. Lett. Rev., 7, 95 (2014); https://doi.org/10.1080/17518253.2014.895867.

M. Nikpassand, L.Z. Fekri, N. Changiz and F. Imani, Lett. Org. Chem., 11, 29 (2014); https://doi.org/10.2174/157017861101140113160517.

A.M. Abdel Hameed, Environ. Chem. Lett., 13, 125 (2015); https://doi.org/10.1007/s10311-015-0494-6.

A. Abdel-Aziem, Int. J. Pharm. Pharm. Sci., 7, 61 (2015).

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I.J. Bruno, J.C. Cole, M. Kessler, J. Luo, W.D.S. Motherwell, L.H. Purkis, B.R. Smith, R. Taylor, R.I. Cooper, S.E. Harris and A.G. Orpen, J. Chem. Inf. Comput. Sci., 44, 2133 (2004); https://doi.org/10.1021/ci049780b.

D. Cremer and J.A. Pople, J. Am. Chem. Soc., 97, 1354 (1975); https://doi.org/10.1021/ja00839a011.

Issue

Vol. 29 No. 12 (2017): Vol 29 Issue 12

Synthesis of N-Containing Heterocycles via Mechanochemical Grinding and Conventional Techniques

Corresponding Author(s) : Amira A. El-Sayed

Abstract

Keywords

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