An Efficient and Convenient Procedure for Preparation of 5-Arylidene Barbituric Acid Catalyzed by ZrO2/SO42- Solid Superacid with Grinding

Abstract

An efficient and convenient approach to the condensation reaction of aromatic aldehydes and barbituric acid using ZrO₂/SO₄^2- solid superacid as catalyst with grinding at room temperature (without any solvent) is described. This method provides several advantages such as neutral condition, high yields and environment friendly.