Synthesis of 3-Phenylimino-4-[2'-(substituted)alkyl/ benzylidene amino]phenyl-5-arylimino-1,2,4-dithiazolidines and Their Antimicrobial Activity

Abstract

Several 3-phenylimino-4-[2′-(substituted)alkyl/benzylidene amino]phenyl-5-arylimino-1,2,4-dithiazolidines have been synthesized by the interaction of 1-phenyl-3-[2′-(substituted)alkyl/benzylidene amino]phenyl thiocarbamides with N-aryl-S-chloro isothiocarbamoyl chlorides. The present compounds in the form of monohydrochlorides have been isolated. These compounds on basification with aqueous ammonia solution afforded free bases. These compounds were successfully brominated into their dibromo derivatives. The structures of these compounds were confirmed on the basis of elemental analysis and spectral data and evaluated for their antimicrobial activity against gram positive and gram negative bacteria.