Synthesis and Antiinflammatory Evaluation of Some New Thiophene Analogs

Abstract

The synthesis of 2-amino-3-carboxyanilido-6-N-methyl piperidino thiophene (2) was synthesized via a multicomponent condensation between sulphur, N-methylpiperdin-4-one and cyanoacetanilide adapting Gewald reaction. It was condensed with different substituted aryl aldehydes to yield 10 thiophene analogs (3a-j). Later 2 was reacted with acetic anhydride and chloroacetylchloride to form 4 and 5. Finally compound 5 was reacted with morpholine and piperazine anhydrous to form 6 and 7. The compounds were characterized by spectral data and  were subjected to antiinflammatory activity.