Synthesis, Antiinflammatory, Antioxidant and Antibacterial Activities of 7-Methoxy Benzofuran Pyrazoline Derivatives

Abstract

Chalcones were prepared from 2-acetyl-7-methoxy benzofuran and condensed with different aromatic acid hydrazides to get corresponding pyrazolines. The structures of all these compounds have been established on the basis of analytical and spectral data. Compounds have been screened for antiinflammatory, antioxidant and antibacterial activities. Among seven compounds that were screened for antiinflammatory activity, compounds 4g and 5m showed 83.89 and 80.49 % inhibition, respectively of oedema volume, while the standard drug (ibuprofen) showed inhibition of 91.93 %. Compounds 4k and 5h showed moderate activity 72.79 and 59.57 %. The values are statistically significant against the control at p < 0.05. All the 30 compounds were screened for antioxidant activity at 250, 100 50, 25 and 10 μg concentration against standard drug ascorbic acid. Compounds 4g, 4h, 4k, 4m, 5g, 5h, 5k and 5m showed excellent antioxidant activity as compared with ascorbic acid. Among 30 compounds that were screened against two gram +ve (S. aureus and B. subtilis) and two gram -ve (E. coli and P. aeruginosa) organisms, compounds possessing p-chloro, p-fluoro,2-amino-5-bromo,2-hydroxy-5-nitro and 3,5-dichloro on phenyl ring showed good activity against E. coli and B. subtilis and the activity is comparable with that of standard drug ciprofloxacin.