Antimicrobial Activity of 3,5-Diaryl-4-bromo-1-substituted Pyrazoles

Abstract

1-(2-Hydroxy-3,5-dichlorophenyl)-3-aryl-2-bromopropan-1,3-diones were prepared by the action of bromine on 1-(2-hydroxy-3,5-dichlorophenyl)-3-aryl-propan-1,3-diones. The 3,5-diaryl-4-bromo-1-substituted pyrazoles have been synthesized by refluxing 1-(2-hydroxy-3,5-dichlorophenyl)-3-aryl-2-bromo-propan-1,3-diones with isonicotinic acid hydrazide, semicarbazide, thiosemicarbazide in ethyl alcohol for about 2.5 h in basic medium. The structures of these compounds have been characterized by spectral analysis (NMR and IR). Purity of these heterocycles was checked by TLC. These compounds were testred for antimicrobial activity against pathogenic bacterial and are found to have remarkable activity.