Convenient and Improved One Pot Synthesis of Imidazole
Corresponding Author(s) : MANDAVA V. BASAVESWARA RAO
vbrmandava@yahoo.com
Asian Journal of Chemistry,
Vol. 19 No. 7 (2007): Vol 19 Issue 7
Abstract
An improved and convenient one pot synthesis of 99 % pure imidazole using (40.0 w/w) glyoxal (1 mol), 25 % aquous ammonia (4 mol) and 35 % formaldehyde (w/w) (1.125 mol) under the temperature conditions of 70-90°C. Various combinations of ammonia, glyoxal and formaldehyde are studied. When the reactions was carried out using ammonia four times of that of glyoxal and formaldehyde 1.125 times to that of glyoxal, it was observed that the better yields of imidazole are obtained with high purity.
Keywords
Synthesis
Imidazole
Heterocycle
Drug intermedicate
Ammonia
Formaldehyde
Glyoxal
PRASANTHI, V., SIVANADH, M., NAGESWARA RAO, K., & V. BASAVESWARA RAO, M. (2010). Convenient and Improved One Pot Synthesis of Imidazole. Asian Journal of Chemistry, 19(7), 5778–5780. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/13202
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