Microwave Assisted Synthesis and Biological Evaluation of Hydantoin Derivatives

Abstract

In the present investigation different substituted hydantoins and their N-Mannich bases were synthesized under microwave and evaluated for their anticonvulsant activity. The rapid and highly efficient synthesis of hydantoin derivative can be achieved under microwave irradiation which results in the improvement in yield and reduction in time of reaction. Among the 5,5-disubstituted 2,4-imidazolidinedione (hydantoin) derivatives, the compounds having both alkyl substituents are less active i.e. the latency to induce convulsions is less than that of the compounds having substituent either phenyl or substituted phenyl. [S-2 p < 0.05 and S-4 p < 0.001] Among the N³-aminomethylated derivatives (N-Mannich bases), The compound (S-4B) derived by using unsubstituted primary aromatic amine, is more active than the compound (S-2B) derived by using substituted primary aromatic amine.