Theoretical Study of the Inhibition of ?-Secretase

Abstract

The brain of the human being suffering of the Alzheimer disease undergoes modifications caused by enzymes e.g., β-secretase and γ-secretase. These enzymes produce fragments of amyloid β. The inhibition of the cleavage of this amyloïd β by enzymes β and γ-secretase prevents the amyloïd forming deposits plates and can improve the efficiency of the system of the elimination. Our research objective is to study the inhibition of the β-secretase by the methods of molecular modelling.