Synthesis and Elucidation of 4-bis(2-Chloroethyl)- amino-L-phenylalanine

Abstract

In this research, synthesis of 4-bis(2-chloroethyl)amino- L-phenylalanine (melphalan) was carried out in several steps, starting with the amino acid, DL-phenylalanine. The structure of all the intermediates and the final product, melphalan, was determined by using various spectroscopic techniques.