Synthesis and Biological Activity of 2-(3-Carboxy phenyl)- 5-(4-substituted phenyl)-1-acetyl-2-pyrazolines

Abstract

3-Aminoacetophenone was diazotized and reacted with sodium cyanide to yield 3-cyano acetophenone (1). 3-Cyano acetophenone was treated with conc. sulphuric acid to obtain 3-carboxy acetophenone (2) which on condensation with various aromatic aldehydes in hydrotopes afforded substituted chalcones (3a-e). The chalcones (3a-e) on cyclization with hydrazine hydrate in glacial acetic acid furnished 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines (4a-e). The constitution of the products was supported by IR, NMR, Mass spectral data and elemental analysis. All the compounds synthesized have been screened for their biological activity.