An Improved Process for the Preparation of 4-(N,N-Disubstituted amino)butaraldehyde Acetals

Abstract

An improved manufacturing process has been developed by performing the reaction of 4-chloro butaraldehyde (3) generated in situ from commercially available starting material sodium salt of 4-chloro-1-hydroxy butane sulphonic acid (4) with methanol or ethanol and further on displacement of alkyl chloride with aqueous dimethyl amine furnished title compounds 1 and 5. The improved process allows to manufacture the intermediates 1 and 5 at considerably low cost and in higher yield.