Synthesis, Antibacterial and Antitubercular Evaluation of Some 1,3,4-Oxadiazole Analogues

Abstract

Reaction of 5-(3'-pyridyl)-Δ⁴-1,3,4-oxadiazole-2-thione   (2) with appropriately N-substituted-β-chloropropionamides   in aqueous KOH yielded corresponding 2-(N-substituted carboxamidomethylthio)-   5-(3'-pyridyl)-1,3,4-oxadiazoles (3).   Structures of various compounds (3a-i) were established by   means of elemental analyses and spectral data. All of these   compounds were screened for antibacterial and antitubercular   activities. Antitubercular activity was done at 50 μg/mL against   Mycobacterium tuberculosis H37Rv strain and antibacterial   activity was carried out against E. coli, S. aureus, S. typhii   and P. aeruginosa at the concentrations of 50 and 100 μg/mL.   Compounds 3b, 3c, 3g, 3h and 3i showed moderate to excellent   antibacterial activity while all but 3f exhibited maximum   inhibition against mycobacteria.